Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review

• 作者: Shang-Li Ji Shi-Bo Tang
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: GLAUCOMA RETINAL GANGLION CELLS induced PLURIPOTENT stem CELLS DIFFERENTIATION
• 年，卷（期）: 2019,（1）
• 页码范围: 152-160
• 页数: 9页
• 分类号: R

摘要

Glaucoma is a common optic neuropathy that is characterized by the progressive degeneration of axons and the loss of retinal ganglion cells(RGCs). Glaucoma is one of the leading causes of irreversible blindness worldwide. Current glaucoma treatments only slow the progression of RGCs loss. Induced pluripotent stem cells(iPSCs) are capable of differentiating into all three germ layer cell lineages. iPSCs can be patient-specific,making iPSC-derived RGCs a promising candidate for cell replacement. In this review, we focus on discussing the detailed approaches used to differentiate iPSCs into RGCs.