Study of Cystatin C as Early Biomarker of Nephropathy in Patients with Type 2 DM and Risk Stratification in Tarnaka Hospital of Hyderabad City in India

• 作者: Abbas Asaad Alhussein Arkan Majhool H.A.ALsailawi Mustafa Mudhafar
• 来源期刊: 美中医学:英文版
• 学科: 医学
• 关键词: CYSTATIN C DIABETIC nephropathies ALBUMINURIA
• 年，卷（期）: 2019,（5）
• 页码范围: 232-241
• 页数: 10页
• 分类号: R73

摘要

This study was done to evaluate clinical usefulness of cystatin C levels of serum and urine in predicting renal impairment in normoalbuminuric patients with type 2 diabetes and to evaluate the association between albuminuria and serum/urine cystatin C.Type 2 diabetic patients(n=200)with normoalbuminuria(n=45),microalbuminuria(n=83)and macroalbuminuria(n=42)were enrolled.Creatinine,urinary albumin levels,serum/urine cystatin C and estimated glomerular filtration rate(eGFR by MDRD(Modification of Diet in Renal Disease)and CKD-EPI(Chronic Kidney Disease Epidemiology Collaboration equations))were determined.The cystatin C levels of serum and urine increased with increasing degree of albuminuria,reaching higher levels in macroalbuminuric patients(p<0.001).In multiple regression analysis,C-reactive protein(CRP),sex,albumin-creatinine ratio(ACR)and eGFR affected serum cystatin C.Urine cystatin C was affected by triglyceride,age,eGFR and ACR.In multivariate logistic analysis,cystatin C levels of serum and urine were identified as independent factors associated with eGFR<60 mL/min/1.73 m^2 estimated by MDRD equation in patients with normoalbuminuria.On the other hand,eGFR<60 mL/min/1.73 m^2 estimated by CKD-EPI equation was independently associated with low level of high-density lipoprotein in normoalbuminuric patients.The cystatin C levels of serum and urine could be useful markers for renal dysfunction in type 2 diabetic patients with normoalbuminuria.