Cannabidiol (CBD) Prevents Palmitic Acid-Induced Drop in Mitochondrial Membrane Potential

• 作者: M. Tarshis R. Gallily R. Vogt Sionov Z. Yekhtin
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: CBD MITOCHONDRIAL MEMBRANE Potential MACROPHAGES MICROGLIA Palmitic Acid
• 年，卷（期）: 2019,（9）
• 页码范围: 387-395
• 页数: 9页
• 分类号: R73

摘要

Exposure of macrophages and microglia cells to the saturated palmitic acid (PA) leads to reduction in the mitochondrial membrane potential (), shrinkage of the cells and apoptosis. Here we show that the Cannabis component Cannabidiol (CBD) rescues both macrophages and microglia cells from the detrimental effects of PA. CBD prevents the shrinkage in cell size and the reduction incaused by PA. The protective effect of CBD on the macrophage mitochondria is important for sustaining the macrophage population even under the immunosuppressed conditions caused by this drug. To a similar extent, the antagonistic effect of CBD on PA-mediated microglia cytotoxicity is important for its role in neuroprotection.