Role of colonoscopy in diagnosis of capecitabine associated ileitis: Two case reports

• 作者: Ahmad Nakshabandi Alexander E Dao Aline Charabaty Angela Hsu Anita Sivaraman Mark Mattar Rohan Mandaliya Sandeep Nadella
• 来源期刊: 世界胃肠内镜杂志:英文版(电子版)
• 学科: 医学
• 关键词: CAPECITABINE XELODA 5-FLUOROURACIL ILEITIS Ileocolitis COLONOSCOPY Case report
• 年，卷（期）: 2019,（5）
• 页码范围: 383-388
• 页数: 6页
• 分类号: R

摘要

BACKGROUND Capecitabine is considered a first line agent in adjuvant therapy for breast and colorectal cancer. However, cases of severe diarrhea have been reported with increasing frequency in recent years. When diarrhea is severe and prolonged, capecitabine associated ileitis should be considered as a possible etiology. CASE SUMMARY Herein, we present two cases of capecitabine ileitis, specifically involving the terminal ileum and ascending colon. We will demonstrate the disease course and treatment modalities applied to alleviate this condition, as well as discuss the merits of using colonoscopy to aid in diagnosis. CONCLUSION Ultimately our cases demonstrate that symptomatic management with traditional anti-diarrheal medications is largely ineffective. Prompt recognition and discontinuation of capecitabine is an imperative step in proper management of this condition and colonoscopy with biopsy can be helpful when the diagnosis is unclear.