Bioinformatics Analysis of the Interaction between Coat Protein and Nuclear Shuttle Protein in <i>Babuvirus</i>

• 作者: Jianhua Wang Naitong Yu Naixin Yu Qin Zhou Xiaobao Zheng Zhixin Liu
• 来源期刊: 美国植物学期刊(英文)
• 学科: 医学
• 关键词: Babuvirus Coatprotein NUCLEAR SHUTTLE PROTEIN Interaction BIOINFORMATICS Analysis
• 年，卷（期）: 2019,（4）
• 页码范围: 622-630
• 页数: 9页
• 分类号: R73

摘要

Protein and protein interactions play important roles in many biological processes and are responsible for carrying out the function of biological regulatory network in living organisms. Previous study indicated that Banana bunchy top virus (BBTV) coat protein (CP) interacted with BBTV nuclear shuttle protein (NSP). However, the protein and protein interaction and the binding affinity of CP and NSP in Babuvirus are remaining unclear. In this study, the CPs and NSPs proteins of BBTV, Abaca bunchy top virus (ABTV) and Cardamom bushy dwarf virus (CBDV) were used for bioinformatic analysis. The binding free energy and the dissociation constant of the possible interaction proteins were tested in PPA-Pred2, and the results confirmed CP interaction with NSP in Babuvirus. The study will help us to understand the interaction between viral protein and viral protein, and the pathogenesis mechanism of Babuvirus in host plants.