Mode of Action and Cytotoxicity of Bioactive Compounds Produced by Streptomyces sp. KB1

• 作者: Kittisak Chawawisit Monthon Lertcanawanichakul
• 来源期刊: 药剂与药理学:英文版
• 学科: 医学
• 关键词: ANTI-MRSA activity bioactive compounds MODE of action cytotoxicity STREPTOMYCES sp. KB1 TISTR 2304
• 年，卷（期）: 2019,（9）
• 页码范围: 499-503
• 页数: 5页
• 分类号: R

摘要

Rapid emergence of methicillin-resistant Staphylococcus aureus (MRSA) has led to search of a novel bioactive compounds from natural resources. This study was aimed to determine the mode of action of bioactive compounds produced by Streptomyces sp. KB1 TISTR 2304 against MRSA, including cytotoxicity against mature brine shrimp. The mode of action and cytotoxicity of bioactive compounds were performed by observing the tested MRSA cells with a scanning electron microscope and evaluated by the brine shrimp lethality bioassay, respectively. The results indicated that bioactive compounds had the mode of action at the cell wall and also showed the moderate cytotoxic activity. This study concluded that the bioactive compounds produced from strain KB1 can be used as a model for novel anti-MRSA drug development.