Rare variants in novel and known genes associated with primary angle closure glaucoma based on whole exome sequencing of 549 probands

• 作者: Jiamin Ouyang Qingjiong Zhang Shiqiang Li Wenmin Sun Xiaoyun Jia Xing Liu Xueqing Li Xueshan Xiao
• 来源期刊: 遗传学报
• 年，卷（期）: 2019,（7）
• 所属期刊栏目: Letter to the Editor
• 页码范围: 353-357
• 页数: 5页
• 语种: 英文

摘要

Primary angle closure glaucoma (PACG) is one of the most common causes of irreversible blindness in Asia and about 80％ of PACG are present in Asia (Song et al., 2017).Genetics plays an important role in the development of PACG (Gramer et al., 2014).Recently, eight common SNPs were found to be strongly associated with PACG (Vithana et al., 2012;Khor et al., 2016) and mutations in MYRF cause high hyperopia accompanied with PACG (Xiao et al.,2019).