Comparative Evaluation of Antioxidant Enzymes and Serum Selenium Levels in Libyan Atherosclerotic Patients

• 作者: Abdurrahman Rhuma Eenas Aboulmeedah Maryouma Enaami Nadia Alghazir Rabia Alghazeer Sana Elgahmasi Zohra Almukthar
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: ATHEROSCLEROSIS Free RADICALS OXIDATIVE Stress ANTIOXIDANTS
• 年，卷（期）: 2019,（7）
• 页码范围: 51-69
• 页数: 19页
• 分类号: R5

摘要

Introduction: Atherosclerosis is the major source of morbidity and mortality in the developed countries like Libya. Oxidative stress represents a risk factor and plays a key role at several steps of atherosclerosis. Formation of atherosclerotic plaques is the main reason for coronary artery disease. Aim: This study is aimed to assess the impact of the imbalance between body oxidants and antioxidants (oxidative stress) and its involvement in developing and severity of atherosclerosis in atherosclerotic with and without diabetes Libyan patients. Methods: The study sample comprised of atherosclerosis with and without diabetes patients (n = 73), as well as healthy controls (n = 27). Blood samples were collected to determine the levels of malonaldehyde (MDA) as oxidative biomarker, serum selenium level, total antioxidant status (TAS) level and some antioxidant enzymes including glutathione peroxidase (GPx), Catalase (Cat) and superoxide dismutase (SOD). Additionally, oxidant/antioxidant status was compared between atherosclerotic patients with and without diabetes in comparison to controls. Results: The results indicated a significant increase in MDA level among atherosclerotic patients compared to healthy subjects (P Conclusion: Determination of antioxidative defense markers contributes to understanding the effect of oxidative stress on the development and the prevention of cardiovascular disease.