Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial

• 作者: Ibo Chukwunenye Chukwu Nwafor Johnbosco Ifunanya Obi Chuka Nobert Onuchukwu Victor Uchenna Onwe Blessing Ugoji Darlington-Peter Chibuzor
• 来源期刊: 妇产科期刊(英文)
• 学科: 医学
• 关键词: Tranexamic Acid MATERNAL MORTALITY POSTPARTUM HAEMORRHAGE
• 年，卷（期）: 2019,（6）
• 页码范围: 914-922
• 页数: 9页
• 分类号: R73

摘要

Objective: To evaluate the efficacy of tranexamic acid for prevention of postpartum haemorrhage among women undergoing cesarean section who were at high risk of postpartum hemorrhage. Materials and Method: This was a double blind randomized controlled trial conducted at the Alex Ekwueme Federal University Teaching Hospital Abakaliki from January 2016 to December 2017. One hundred and sixty-eight parturients at high risk of postpartum haemorrhage who underwent caesarean section were randomly assigned to receive either tranexamic acid or placebo prior to skin incision. Results: The result of the study showed that the need for additional uterotonic was higher in women in the placebo arm when compared with women in the tranexamic arm of the study (7.4% versus 33.3%, respectively). The incidence of primary post-partum hemorrhage (blood loss > 1000 ml) was significantly lower in the tranexamic acid group compared to placebo group (11.9% versus 50%, respectively, P-value Conclusion: Intravenous tranexamic acid given prior to skin incision at caesarean section reduced the need for additional uterotonics and incidence of primary postpartum among high risk women.