Equilibria between the K+ binding and cation vacancy conformations of potassium channels

• 作者: Bo Zhang Changlin Tian Hao Dong Jun Liang Mu Yu Penglin Xu Ting Zhou Xiao Zheng Xiaoying Cai Yao He
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2019,（7）
• 所属期刊栏目: LETTERS
• 页码范围: 533-537
• 页数: 5页
• 语种: 英文

摘要

Dear Editor, Potassium channels are integral membrane proteins that selectively conduct K+ ions across cell membrane (Hille, 2001). They play essential roles in maintaining cellular ionic homoeostasis and generating action membrane potentials in excitable cells. The mechanism of K+ selectivity has been evaluated in many biophysical and physiological studies (Zhou et al., 2001;Liu et al., 2015;Schewe et al., 2016). A highly conserved signature sequence, TVGYG, in the selectivity filter of potassium channels (e.g., KcsA) is known to coordinate K+ions (Zhou et al., 2001).