Insights into the pathogenesis of cystoid macular edema: leukostasis and related cytokines

• 作者: Hye-Eun Byeon Kihwang Lee Seung Yeop Lee Yoo-Ri Chung Young Ho Kim
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: CYSTOID MACULAR EDEMA CYTOKINE leukostasis PATHOGENESIS
• 年，卷（期）: gjykzzywb_2019,（7）
• 页码范围: 1202-1208
• 页数: 7页
• 分类号: R

摘要

Cystoid macular edema(CME) is the abnormal collection of intraretinal fluid in the macular region, especially in the inner nuclear and outer plexiform layers. CME leads to severe visual impairment in patients with various retinal diseases, such as diabetic retinopathy, retinal vascular occlusion, choroidal neovascularization, and uveitis. Although various retinal conditions lead to CME, a shared pathogenesis of CME is involved in these diseases. Accordingly, the pathogenesis of CME based on vasogenic mechanisms is first discussed in this review, including vascular hyperpermeability, leukostasis, and inflammation. We then describe cytotoxic mechanisms based on retinal Müller cell dysfunction. This comprehensive review will provide an understanding of the pathogenesis of CME for potential therapeutic strategies.