Glutathione Enzymes and Liver Injury in Acute Dengue Viral Infection

• 作者: Arjuna De Silva Chandima De Mel Hemantha Peiris Lal Chandrasena Samantha Bandara Sanjay De Mel Suranjith Seneviratne Visula Abesuriya
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: ASPARTATE TRANSAMINASE ALANINE TRANSAMINASE DENGUE GLUTATHIONE Peroxidase GLUTATHIONE REDUCTASE
• 年，卷（期）: 2019,（10）
• 页码范围: 61-71
• 页数: 11页
• 分类号: R51

摘要

Identification of redox markers may be of clinical significance in the management of dengue patients. This study is to identify the association between antioxidant enzymes, hematological parameters and liver transaminases in patients with acute dengue infection. Blood samples were taken from patients on the day of admission, day 05 and 07 from admission for analysis of glutathione peroxidase (GPX), glutathione reductase (GR), aspartate transaminase (AST), alanine transaminase (ALT) and hematological parameters. AST and ALT levels were significantly elevated (p < 0.05) on day 05 in dengue patients. In contrast, GPX and GR showed significantly low levels on day 05 compared to on the day of admission and day 07. Although there was a decline in the trend of platelets towards day 05, values were not significantly different. Dengue associated with liver injury appears to peak around day 05 when the GPX and GR enzymes levels in patients were the lowest suggesting that increased viral load in the acute phase of dengue infection has initiated an antioxidant imbalance. Thus, timely investigation of antioxidant enzymes (GR and GPX) and liver transaminases around day 05 of admission may be of value in the management of patients with dengue infection similar to as seen in platelet counts.