The role of cell mediated immunopathogenesis in thyroidassociated ophthalmopathy

• 作者: Yan Lu Zhen-Mao Wang Zheng-Yan Wang
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: thyroid-associated OPHTHALMOPATHY ORBITAL FIBROBLAST FIBROCYTES IMMUNOPATHOGENESIS
• 年，卷（期）: gjykzzywb_2019,（7）
• 页码范围: 1209-1214
• 页数: 6页
• 分类号: R

摘要

Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the key target and effector cells in its pathogenesis. The orbit infiltrating CD34+ fibrocytes add on to the process by expressing high levels of autoantigens and inflammatory cytokines, while also differentiating into myofibroblasts or adipocytes. This review focuses on the role of orbital fibroblasts and CD34+ fibrocytes in the pathogenesis of TAO, highlighting the basis of emerging treatments.