Genetic monkeys reveal a new role for a longevity protein in embryonic development

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（3）
• 页码范围: 392
• 页数: 1页
• 语种: 英文
• DOI: 10.1093/nsr/nwz051

摘要

As it is involved in boosting lifespan in mammals, SIRT6 has been in the spotlight for years.In mice, SIRT6 overexpression leads to improved health and lifespan extension [1].Animals die soon after birth if SIRT-6 is deficient [2].A recent study in humans showed that SIRT6 mutation causes abnormal brain development and results in embryonic death [3].This suggested that SIRT6 may play a different role in primate development.In a recent study published in Nature, a team of Chinese Academy of Sciences scientists generated a SIRT6-deficient macaque monkey by clustered regularly interspaced short palindromic repeats-Cas9.The study showed that the gene, as well as its well-known role in aging, has an additional function in embryonic development [4].