Interrogating the noncoding genome in a high-throughput fashion

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（3）
• 页码范围: 397-399
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/nsr/nwy138

摘要

The vast majority of the mammalian genome consists of DNAs that do not encode protein sequences.For decades, the functional potentials of these noncoding DNAs have remained poorly understood.Large-scale studies, such as the Encyclopedia of DNA Elements project and genome-wide association studies, have suggested that the noncoding genome functions in a wide variety of biological and physiological process [1].However, it has been technically challenging to attribute functions to a plethora ofnoncoding elements in any given biological con text, largely due to a lack of convenient high-throughput approaches.