Experimental Study of Pratia Extact on Acute Liver Injury in Mice

• 作者: Chanling JIANG Junxiu LI Lichun ZHAO
• 来源期刊: 农业生物技术:英文版
• 学科: 农学
• 关键词: Pratia extact ALCOHOLIC LIVER INJURY CCL4 LIVER INJURY Protective effect
• 年，卷（期）: 2019,（5）
• 页码范围: 142-144
• 页数: 3页
• 分类号: S

摘要

[Objectives] This study was conducted to observe the protective effect of Pratia extract on acute liver injury in mice.[Methods] Mice were randomly divided into 6 groups according to body weight,10 in each group: normal control group,ethanol-induced/CCl4 liver injury model,low-dose,middle-dose and high-dose Pratia extract groups,and bifendatatum group.Except the blank group,other groups were given 50% ethanol intragastrically at a dose of 12 ml/kg to cause acute alcoholic liver injury,or intraperitoneally injected with 10% CCl4 soybean oil solution to cause acute CCl4 liver injury.The serum ALT and AST activity were measured as well as liver SOD and MDA concentrations.[Results] Pratia extract effectively reduced serum ALT and AST,decreased MDA content and increased liver tissue SOD activity.[Conclusions] Pratia extract has certain protective effect on acute liver injury.