Study on the Inhibitory Effect of Scopoletin on Proliferation and Metastasis of Breast Cancer Cells

• 作者: Juan LI Xiaoyan LIU Zhiqiang MEI
• 来源期刊: 农业生物技术:英文版
• 学科: 医学
• 关键词: SCOPOLETIN BREAST cancer Inhibition STUDY
• 年，卷（期）: 2019,（4）
• 页码范围: 110-112
• 页数: 3页
• 分类号: R73

摘要

[Objectives]This study was conducted to investigate the effect of scopoletin on the proliferation of breast cancer cell lines.[Methods]Cell viability,gene expression and cell cycle were measured by cell culture,RT-PCR and flow cytometry.The effects of different concentrations of scopoletin on proliferation and cell cycle of breast cancer cells were compared.[Results]After a certain period of time,the breast cancer cells showed different degrees of apoptosis,and the growth cycle was arrested in the G1 phase,which promoted the down-regulation of three genes in breast cancer metastasis.[Conclusions]The study proves that scopoletin inhibits the proliferation and metastasis of breast cancer cells in a concentration-and time-dependent manner.