Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study

• 作者: Alessandra Mastropasqua Alfonso Senatore DanieleTognetto Giuseppe Di Martino Leonardo Mastropasqua Lisa Toto Luca DiAntonio Marco Ciancaglini Marta Di Nicola Rossella D’Aloisio Silvio Di Staso
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: optical coherence tomography angiography diabetic MACULAR edema INTRAVITREAL DEXAMETHASONE IMPLANT INTRAVITREAL RANIBIZUMAB INJECTIONS
• 年，卷（期）: gjykzzywb_2019,（10）
• 页码范围: 1589-1597
• 页数: 9页
• 分类号: R587.2

摘要

AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological assessments.METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases.RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(P<0.001) without statistically significant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye drops.CONCLUSION: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group.