Noises and Signal-to-Noise Ratio of Nanosize EIS and ISFET Biosensors

• 作者: Ferdinand Gasparyan Ilya Mazo Lusine Gasparyan Vahan Simonyan
• 来源期刊: 生物物理学期刊(英文)
• 学科: 工学
• 关键词: BIOSENSOR Noise Sensitivity SIGNAL-TO-NOISE Ratio
• 年，卷（期）: 2020,（1）
• 页码范围: 1-12
• 页数: 12页
• 分类号: TN3

摘要

The results of comparative theoretical analyzes of the behavior of internal low-frequency noises, signal-to-noise ratio and sensitivity to DNA molecules for EIS and ISFET based nanosize biosensors are presented. It is shown that EIS biosensor is more sensitive to the presence of DNA molecules in aqueous solution than ISFET sensor. Internal electrical noises level decreases with the increase of concentration of DNA molecules in aqueous solution. In the frequency range 10−3 - 103 Hz noises level for EIS sensor about in three orders is higher than for ISFET sensor. In the other hand, signal-to-noise ratio for capacitive EIS biosensor is much higher than for ISFET sensor.