Coordination Behavior and Biological Activity of Some Transition Metal Complexes with 2-Acetyl and 2-Formyl-3-Amino-1,4-Naphthoquinone Ligands

• 作者: Fatma S. M. Hassan Mahmoud Fayez Nadia Abdalla
• 来源期刊: 无机非金属材料(英文)
• 学科: 化学
• 关键词: 1 4-Naphthoquinone Transition Metal Complex Antibacterial Activity
• 年，卷（期）: wjfjsclyw,（2）
• 页码范围: 15-29
• 页数: 15页
• 分类号: O62

摘要

<div style="text-align:justify;"> <span style="font-family:Verdana;">The aim of this work is to synthesize, characterize and evaluate the biological activity of 2-acetyl and 2-formyl-3-amino-1,4-naphthoquinone (L<span style="white-space:nowrap;">¹</span> - L<span style="white-space:nowrap;">²</span>) and their metal-Co(II), Ni(II) and Cu(II) chelates. The newly chelates were characterized by elemental analysis, IR, mass and <span style="white-space:nowrap;">¹</span>HNMR spectra, thermogravimetric analysis (TGA) and biological activity. The antibacterial and antifungal activities of the ligands and its metal complexes were screened against bacterial species (<span style="white-space:nowrap;"><i>Staphylococcus aureus, Bacillus subtilis and Escherichia coli</i></span>) and fungi (<span style="white-space:nowrap;"><i>Candida albicans</i></span>). Ampicillin and amphotericin were used as references for antibacterial and antifungal studies. The activity data show that the metal complexes have a promising biological activity comparable with parent free ligand against bacterial and fungal species.</span> </div>