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摘要:
In the current report, we describe an 83-year-old biological male who self- identified as a female by legally changing his first and middle names to female ones and whose death certificate states his sex as a female. The medical history of this individual indicated complete penectomy without further specification. Postmortem physical examination revealed an absence of penis with a large scrotum, transposed urethral orifice, and small testes. The histological analysis of the testes identified abnormal epithelium in the seminiferous tubules that lacked germ and Sertoli cells as well as the interstitium without Leydig cells present. The exome sequencing of the individual’s DNA using the Next Generation Sequencing (NGS) Illumina platform revealed no genetic variants associated with either penile or urethral cancer that could have explained the complete penectomy, but pointed toward a potentially impaired production of T3 and T4 thyroid hormones which could account for the observed testicular malformation. Overall, the data obtained raise an important question as to whether the thyroid hormone axis could be an important part of the hormonal architecture supporting male sexual behavior.
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篇名 A Rare Case of 83-Year-Old Transgender Female: Can Thyroid Hormone Deficiency Be Involved in Transgenderism and Gender Dysphoria?
来源期刊 性医学进展(英文) 学科 医学
关键词 Transgenderism GENDER DYSPHORIA Next Generation Sequencing THYROID PEROXIDASE CILIA
年,卷(期) 2020,(2) 所属期刊栏目
研究方向 页码范围 23-40
页数 18页 分类号 R69
字数 语种
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Transgenderism
GENDER
DYSPHORIA
Next
Generation
Sequencing
THYROID
PEROXIDASE
CILIA
研究起点
研究来源
研究分支
研究去脉
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相关学者/机构
期刊影响力
性医学进展(英文)
季刊
2164-5191
武汉市江夏区汤逊湖北路38号光谷总部空间
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82
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0
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