<i>Trypanosoma evansi</i>: A Qualitative and Quantitative Ultrastructural Analysis of the Spleen during Experimental Murine Infections

• 作者: Antonio Roschman-Gonzalez Félix Tejero Hector J. Finol Lucia Proietti d’Empaire Pedro M. Aso
• 来源期刊: 显微镜研究(英文)
• 学科: 医学
• 关键词: Trypanosoma evansi SPLEEN ULTRASTRUCTURE Mouse
• 年，卷（期）: 2020,（3）
• 页码范围: 31-42
• 页数: 12页
• 分类号: R73

摘要

A murine model is used to study qualitatively and quantitatively the splenic ultrastructural changes induced by two <i>Trypanosoma</i><i> </i><i>evansi</i><i> </i>strains derived from naturally infected local equine hosts (<i>Equusasinus</i> and <i>E. caballus</i>);<i>T. evansi</i> causes ultrastructural modifications in the spleen of the infected mice. The modifications include tissular disorganization, fibrosis, mitochondrial swelling, apoptosis and necrosis. The initial phases of the infection are quite similar, whereas the final phases differ qualitatively depending on the strain’s source. The ultrastructural quantitative changes were studied in the reticular splenocytes covering alterations in the area of the cytoplasm and nucleus. Analysis of the results shows the induction of various splenic alterations caused by local <i>T. evansi</i> strains. Also, it was documented that discriminative time modulation, as well as progressive tissular, cellular and subcellular changes, are more associated with derived infections from <i>E. caballus</i> strain.