Synthesis and Crystal Structure Studies of Mitomycin C Dihydrate

• 作者: Heng Zhang Shuang Cao Yingqi Feng Yixin Ren Yongshou Chen
• 来源期刊: 晶体结构理论与应用(英文)
• 学科: 化学
• 关键词: CRYSTAL Structure DIHYDRATE ABSOLUTE CONFIGURATION MITOMYCIN C
• 年，卷（期）: 2020,（2）
• 页码范围: 13-21
• 页数: 9页
• 分类号: O61

摘要

The absolute configuration of mitomycin C was determined?by X-ray single crystal diffraction?(CuKα), and a new?crystalline?dihydrate of mitomycin C had been prepared. The?experiment?result?provides?a definitive answer?to the real absolute configuration of mitomycin C and may put an end to the dispute?that baffles?researchers for decades.?At the same time, some contentious structures?about the mitomycin C in?American Pharmacopoeia?USP36-NF31,?Chinese pharmacopoeia?2015?edtion?and numbers of?literatures are marked. The absolute configuration?is?also verified?by?1D (1H?and?13C) and 2D (HSQC, HMBC,?1H-1H?COSY?and?NOESY) NMR studies?indirectly. Powder X-ray diffraction (PXRD) pattern of the?mitomycin C dihydrate?is similar to that calculated for?it, which?suggests that the purity?of?sample?is excellent.