Correlations of morphology and molecular alterations in traditional serrated adenoma

• 作者: Hongxing Gui Michael A Husson Rifat Mannan
• 来源期刊: 世界胃肠病理生理学杂志:英文版(电子版)
• 学科: 医学
• 关键词: Traditional serrated adenoma Serrated polyps KRAS BRAF COLON
• 年，卷（期）: 2020,（4）
• 页码范围: 78-83
• 页数: 6页
• 分类号: R735.34

摘要

Traditional serrated adenoma was first reported by Longacre and FenoglioPresier in 1990.Their initial study described main features of this lesion,but the consensus diagnostic criteria were not widely adopted until recently.Traditional serrated adenoma presents with grossly protuberant configuration and pineconelike appearance upon endoscopy.Histologically,it is characterized by ectopic crypt formation,slit-like serration,eosinophilic cytoplasm and pencillate nuclei.Although much is now known about the morphology and molecular changes,the mechanisms underlying the morphological alterations are still not fully understood.Furthermore,the origin of traditional serrated adenoma is not completely known.We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity.