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Purpose: This study aimed to characterize mood and quality of life and to examine the associations of these areas with subjective cognitive concerns and attitudes toward genetic testing for the Common Hispanic Mutation, a gene that has been associated with increased risk for CCM1. Method: Fifty-four adults with previous genetic testing for the Common Hispanic Mutation completed a mail survey that included assessments of the above identified areas. Results: Self-reported depressive symptoms and quality of life did not differ between those with positive and negative genetic test results. The negative group expressed a more favorable attitude toward genetic testing (p p = 0.06). Using generalized linear regression, more subjective cognitive concerns were associated with poorer quality of life and more depressive symptoms (p p Conclusions: Subjective cognitive concerns and negative attitudes toward genetic testing may influence emotional well-being after genetic testing for the Common Hispanic Mutation. Additional research is needed that uses objective neuropsychological measures to understand the associations of subjective cognitive concerns, emotional well-being, and cognitive test performance in individuals with CCM1. There is also a need for research that focuses on protective factors and resiliency following genetic testing for CCM1 and the development of mental health interventions to preempt psychosocial difficulties.
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篇名 Subjective Cognitive Concerns and Attitudes toward Genetic Testing Are Associated with Depressive Symptoms and Quality of Life after Genetic Testing for the Cerebral Cavernous Malformation Common Hispanic Mutation (CCM1)
来源期刊 行为与脑科学期刊(英文) 学科 文学
关键词 Quality of Life DEPRESSION Genetic Testing SUBJECTIVE COGNITIVE CONCERNS
年,卷(期) 2020,(2) 所属期刊栏目
研究方向 页码范围 118-127
页数 10页 分类号 H31
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Quality
of
Life
DEPRESSION
Genetic
Testing
SUBJECTIVE
COGNITIVE
CONCERNS
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研究来源
研究分支
研究去脉
引文网络交叉学科
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期刊影响力
行为与脑科学期刊(英文)
月刊
2160-5866
武汉市江夏区汤逊湖北路38号光谷总部空间
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139
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0
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