Research Progress of the Treatment of PD-1 Immune CheckpointInhibitors in Oral Squamous Cell Carcinoma

• 作者: Kesang Li Suying Qian Yetao Wang
• 来源期刊: 肿瘤学研究(英文)
• 学科: 医学
• 关键词: Anti-PD-1 Immune checkpoint inhibitors IMMUNOTHERAPY Oral squamous cell carcinoma
• 年，卷（期）: 2020,（2）
• 页码范围: 9-15
• 页数: 7页
• 分类号: R73

摘要

Targeted immune checkpoint-based immunotherapy has achieved remarkable success in the treatment of malignant tumors.Immune checkpoint inhibitor-programmed cell death protein 1(PD-1)antibody opens a new era of immunotherapy for platinum-refractory recurrent/metastatic oral squamous cell carcinoma(OSCC).The overall survival of patients treated with immunological checkpoint inhibitors was significantly prolonged,and the overall incidence of grade 3-4 drug-related adverse events(AEs)occurred was lower;however,there are still some challenges to the PD-1’s application in OSCC clinic treatment.This article is just to briefly highlight the development of such application to date.