Simultaneous transarterial chemoembolization and radiofrequency ablation for large hepatocellular carcinoma

• 作者: Feng Duan Jie-Yu Yan Li Cui Mao-Qiang Wang Xiao-Hui Li Yan-Hua Bai
• 来源期刊: 世界胃肠肿瘤学杂志:英文版(电子版)
• 学科: 医学
• 关键词: CHEMOEMBOLIZATION RADIOFREQUENCY ablation Hepatocellular carcinoma SIMULTANEOUS treatment TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION
• 年，卷（期）: 2020,（1）
• 页码范围: 92-100
• 页数: 9页
• 分类号: R73

摘要

BACKGROUND Hepatocellular carcinoma(HCC)is a common cancer and a leading cause of tumor-related death.Patients with large HCC(≥8 cm)are at an advanced stage and have poor prognosis,and hepatic resection may not be suitable,and the incidence of postoperative recurrence is high.AIM To evaluate recurrence and mid-term survival of patients with large HCC treated by transcatheter arterial chemoembolization(TACE)and radiofrequency ablation(RFA).METHODS This was a retrospective study.From 2010 to 2013,46 consecutive patients with large HCC were treated with simultaneous TACE and RFA.Thirty-five of 46 patients had a single tumor.Progression-free survival(PFS)and overall survival(OS)were analyzed at 2 years and 3 years,respectively.RESULTS Forty-six patients treated by simultaneous TACE and RFA had no significant complications and treatment was successful.After 3 years,median PFS and OS were 10.21±1.58 mo and 26.44±2.26 mo,retrospectively.The survival rate was 67.5%after 2 years and 55.67%after 3 years.CONCLUSION These preliminary data show that simultaneous TACE and RFA are safe and effective for large HCC.