Optimization of Dosage Regimen of Rezafungin against <i>Candida spp. </i>Based on Pharmacokinetic/Pharmacodynamic Analysis

• 作者: Jiuli Hu Junhui Hu
• 来源期刊: 药理与制药(英文)
• 学科: 数学
• 关键词: Invasive Candidiasis Rezafungin PHARMACOKINETICS/PHARMACODYNAMICS Monte Carlo Simulation
• 年，卷（期）: 2020,（6）
• 页码范围: 79-84
• 页数: 6页
• 分类号: O17

摘要

Invasive candidiasis was the most common nosocomial fungal infection with high morbidity and mortality, which is mainly occurring in immunodeficiency and critical patients. Echinocandins were recommended as first-line drugs for the treatment and prevention of invasive candidiasis. In our study, we aimed to optimize the dosage of Rezafungin against <i><i><span style="font-family:Verdana;">Candida</span></i><span> <i><span style="font-family:Verdana;">spp.</span></i><span style="font-family:Verdana;"> </span></span></i><span style="font-family:Verdana;"> based on pharmacokinetic/pharmacodynamics (PK/PD) analysis. We collected the published data about pharmacokinetic parameters of rezafungin and the MIC distribution of <i></i></span><i><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>spp</i></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">.</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> </span></span></span></i> on <span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">rezafungin</span><i><span style="font-family:Verdana;">.</span></i><span style="font-family:Verdana;"> Monte Carlo simulation was used to calculate probability of target attainment and a cumulative fraction of response to assess the best dosing regimen. The optimal dosage regimen for <i></i></span><i><i><span style="font-family:Verdana;">C.</span></i><span style="font-family:Verdana;"> <i>albicans</i></span> <span style="font-family:Verdana;"></span></i></span><span style="font-family:Verdana;">and <i></i></span><i><i><span style="font-family:Verdana;">C.</span></i><span> <i><span style="font-family:Verdana;">glabrata </span></i><span style="font-family:Verdana;"></span></span></i></span></span><span style="font-family:Verdana;">was 50 mg IV, and the optimal dosage regimen for <i></i></span><i><i><span style="font-family:Verdana;">C.</