Optimizing the Dosage Regimen of Micafungin against <i>Candida spp</i>in HIV Positive Patients with EC Based on Mote Carlo Simulation

• 作者: Hainan Wen Jingyi Zhao Song Jiang Ying Wang Yinhui Yao
• 来源期刊: 预防医学期刊(英文)
• 学科: 医学
• 关键词: Monte Carlo Simulation MICAFUNGIN HIV Positive Patients Esophageal Candidiasis
• 年，卷（期）: 2020,（6）
• 页码范围: 120-125
• 页数: 6页
• 分类号: R97

摘要

The objective of our study was to explore the possibility of the antifungal efficacy of various micafungin dosage regimens against <i>Candida spp</i> in HIV positive patients with EC. According to pharmacokinetic/pharmacodynamics parameters of micafungin in HIV positive patients and MICs distribution of micafungin against <i>Candida spp</i>. in published studies, the dosage regimens of micafungin were 50, 100 and 150 mg QD iv. Monte Carlo Simulation analysed the probability of target attainment and cumulative fraction of response. The results showed that micafungin has good antifungal effect in treating HIV positive patients with EC when pathomycetes are <i>Candida albicans</i>, <i>Candida glabrata</i> or <i>Candida tropicalis</i>, in dosage at 100 mg QD and 150 mg QD.