Epigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection

• 作者: Lanfeng Wang Weiwei Wang Zhaoning Wang
• 来源期刊: 生物物理学报:英文版
• 学科: 医学
• 关键词: HBV CCCDNA MINICHROMOSOME Epigenetic regulation
• 年，卷（期）: swwlxbywb_2020,（4）
• 页码范围: 115-126
• 页数: 12页
• 分类号: R51

摘要

Hepatitis B is caused by hepatitis B virus(HBV),and persistent HBV infection is a global public health problem,with 257 million people as HBV chronic carriers.Viral covalently closed circular DNA(cccDNA)is a key factor to establish persistent infection in infected hepatocytes.Current antiviral therapies have no direct impact on pre-existing cccDNA reservoir,which can be assembled into minichromosome by hijacking host factors.Understanding the mechanisms of epigenetic regulation in cccDNA minichromosome is crucial to develop new therapy on cccDNA,an attractive target for HBV cure.This review summarizes the current advances in epigenetic regulation of cccDNA minichromosome,which might provide clues to novel druggable targets to cure hepatitis B by either silencing or eliminating cccDNA reservoir.