Acetylation of Starch Extracted from Rejected Fruits of <i>Musa ×paradisiaca L.</i>to Obtain a Pharmaceutical Disintegrant

• 作者: Eduardo Mayorga Javier Santamaría- Aguirre Karla Dumancela
• 来源期刊: 药理与制药(英文)
• 学科: 数学
• 关键词: Modified Banana Starch ACETYLATION Swelling Capacity DISINTEGRANT Dissolution Profile
• 年，卷（期）: 2020,（6）
• 页码范围: 118-126
• 页数: 9页
• 分类号: O17

摘要

There are many natural sources to obtain pharmaceutical grade starch, one of which is banana (<i><i><span style="font-family:Verdana;">Musa</span></i><span style="font-family:Verdana;"> × </span><i><span style="font-family:Verdana;">paradisiaca L</span></i><span style="font-family:Verdana;">.</span></i>);nevertheless, the use of native starch has certain disadvantages compared to modified starches, whose disintegrating properties are better. In this study, starch extracted from rejected fruits of <i><i><span style="font-family:Verdana;">Musa</span></i><span style="font-family:Verdana;"> × </span><i><span style="font-family:Verdana;">paradisiaca L</span></i><span style="font-family:Verdana;">.</span></i>, was modified by acetylation, under the following optimized experimental conditions: 130 mL acetic anhydride, 3 mL sodium hydroxide 50% p/v for each 15 grams of native starch, at 123℃ during 3 hours. The reaction resulted in a modified green banana starch with twice as much swelling capacity compared to unmodified (native) starch;acetylation was verified by infrared spectroscopy and degree of substitution of acetyl groups by back titration. The dissolution profiles of Ibuprofen tablets <span style="font-family:Verdana;">made </span><span style="font-family:Verdana;">with</span><span> </span><span style="font-family:Verdana;">banana modified starch and commercial disintegrant, ha</span><span style="font-family:Verdana;">ve</span><span style="font-family:Verdana;"> no differences according with their similarity factor</span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""> <i><span style="font-family:Verdana;">f</span></i>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">. It is concluded that it is feasible to use green banana starch modified through acetylation as a pharmaceutical disintegrant.</span></span>