HAZOP analysis is the best tool for process hazard identification and operability analysis so far which is applicable to the entire life cycle reviews of the projects and periodical reviews of the operational plants, covering three aspects of process, equipment and changes. This method has experienced more than half a century of development abroad, but in China, on the whole, it is still in the primary stage of promotion and adoption so there is not much experience and factually there are many issues in practice. This study delivers a comprehensive explortion of ten aspects of the major issues frequently in our country which impacts the effects of HAZOP , and on the basis proposes the countermeasures underpinned with domestic and foreign good practices to allow HAZOP fully to play the important role, maximize its value so that the risks of the projects and operational plants can be well addressed.