<i>Cryptococcus</i>and <i>Cryptococcosis</i>in Human and Animal Model: An Overview

• 作者: Amanda Latércia Tranches Dias André Gasparetto Claudete Rodrigues Paula Débora Moreira Diniz Pereira Leite-Jr. Elisangela Santana de Oliveira Dantas Eriques Gon?alves da Silva Francisco de Assis Baroni Marcos Ereno Auler Margareth Léa da Silva Maia Regina Teixeira Barbieri Ramos Rinaldo Ferreira Gandra Sandra Marilia de Souza Silva Valéria Tognato Costa
• 来源期刊: 微生物学(英文)
• 学科: 医学
• 关键词: Cryptocococcus CRYPTOCOCCOSIS Animal Model CRYPTOCOCCUS neoformans Cryptococcusgattii VIRULENCE Related Factors
• 年，卷（期）: 2020,（4）
• 页码范围: 180-193
• 页数: 14页
• 分类号: R73

摘要

Background: Yeasts from the genus Cryptococcus (species C. neoformans and C. gattii) are opportunistic pathogens that afflict humans with low immunity caused by diseases such as AIDS or by the usage of immunosuppressive drugs. It is a fatal disease that has been studied around the whole world and its most fatal form is the brain cryptococcosis. Purpose: The present review describes the disease from pathogen isolation, the various clinical presentations of the disease, the most important virulence factors of yeast in human and animal model and their clinical issues. Methods: On this review, several published studies about the disease are presented. Results: Numerous researches have been done worldwide in order to find a kind of therapy that is more effective against the disease. Amphotericin B, in all forms is still the drug of choice in the treatment of the cryptococcosis. Fluconazole, as well as voriconazole in combination with amphotericin B, is recommended in the cases of treatment failure. Conclusion: This study presented has elucidated a little more about the disease. Further studies should be conducted to find more diagnoses that are accurate as well as more effective treatments for eradicating the disease. In this study, the bibliographic survey makes reference to the world literature;with regard to ecology, taxonomy, mains factors related to virulence, the clinical manifestations, the action of antifungal drugs and histopathological analysis used in an animal model, were the objectives deleterious aspects of this study, thus informing, in a simple way, the importance of this microorganism for research and researchers working with this global disease, called Cryptococcosis.