Background:Vitamin D and vitamin D receptors are closely related to human bone,muscle,fat and other tissues.The traditional role of vitamin D is centered on regulating calcium and bone metabolism.In recent years,studies have shown that vitamin D and vitamin D receptors can affect specific cellular pathways in the process of malignant tumors,and affect tumor cell apoptosis,differentiation and metastasis.In addition,they can also enhance the effects of chemical drugs and alleviate the adverse reactions of cachexia.This article summarizes the anti-tumor mechanism of vitamin D and its receptors.