Dysfunction of Fronto-Subcortical Circuitry in Fronto-Temporal Dementia

• 作者: E. B. Sougey S. Laurentino
• 来源期刊: 精神病学期刊(英文)
• 学科: 医学
• 关键词: Frontotemporal Dementia Fronto-Subcortical Circuitry Basal Ganglia NEUROTRANSMITTERS Fronto-Subcortical Syndrome
• 年，卷（期）: 2020,（4）
• 页码范围: 171-186
• 页数: 16页
• 分类号: R74

摘要

In the last years, some studies have shown that behavior disorder seems in frontotemporal dementia is related to dysfunction in the fronto-subcortical circuitry. <strong>Objectives:</strong> We did a narrative literature review concerning fronto-subcortical circuitry and frontotemporal dementia (FTD). <strong>Methods:</strong> Manuscripts related to fronto-subcortical network and frontotemporal dementia were selected for further analysis. <strong>Results:</strong> From the executions of simple motor actions to the most complex behaviors like goal-direct behavior and social cognition, the fronto-subcortical circuitry involves an intrigued network of fibers that reaches to basal ganglia nuclei. Recently, researchers have shown five parallel fronto-subcortical circuits integrating and segregating information from the frontal cortex to basal ganglia. Understanding the relationship between the fronto-subcortical circuit dysfunctions and neurodegenerative diseases requires studying the functional anatomy and neurochemical basis involved.<strong> Conclusions:</strong> In this view, it is essential to review the functional anatomy of the fronto-subcortical network, and it’s correlated with clinical aspects to pursuing a better therapeutic approach.