Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy

• 作者: Cheng Yi Chengli Yang Kun Shi Ruoyu Zha Xiaohan Zhou Ying Hao Zhiyong Qian
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 医学
• 关键词: NANOTECHNOLOGY EGFR TYROSINE KINASE INHIBITOR Cancer therapy
• 年，卷（期）: 2020,（1）
• 页码范围: 26-41
• 页数: 16页
• 分类号: R73

摘要

Oral tyrosine kinase inhibitors(TKIs) against epidermal growth factor receptor(EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery.