Expression and prognosis analyses of SNX8 in human gastric cancer

• 作者: Bo Liu Zi-Xiang Kou
• 来源期刊: 精准医学研究
• 学科: 医学
• 关键词: BIOMARKER Gastric cancer PROGNOSIS SNX8
• 年，卷（期）: 2020,（4）
• 页码范围: 153-164
• 页数: 12页
• 分类号: R73

摘要

Background:Associated with the Alzheimer's disease,the SNX8,reported as aβ-amyloid toxicity enhancer,is a PX-BAR domain sub-family of sorting nexins.Nonetheless,though the specific role of SNX8 was evident in cases of gastric cancer,very little is known about the function and expression SNX8 in gastric cancer.Methods:Using The Cancer Genome Atlas and the Oncomine databases,the methylation and the SNX8 expression were evaluated.With the Kaplan-Meier Plotter and UALCAN database,the relationship between the several clinical parameters and SNX8,along with the survival information was revealed.Results:SNX8 was upregulated in various subtypes of gastric cancer compared with the matched normal individuals.The expression of SNX8 was also overexpressed regardless of cancer stage(S1,S2,S3,and S4),tumor grade(G1,G2,and G3),gender(male and female),race(Caucasian,African-American,and Asian),age(20-40,41-60,61-80,and 81-100 Yrs),helicobacter pylori infection,and histological subtype.And we revealed that the SNX8 expression level may be correlated with DNA methylation and copy number alterations in the gastric cancer.Besides,a positive correlation between SNX8 and CHST12 was confirmed.Conclusion:In the prognosis of gastric cancer SNX8 could be used as a predictive biomarker.To investigate the molecular mechanism of the value of SNX8 in gastric cancer,detailed experiments are needed.