Synergistic Effect of a Selective Serotonin Reuptake Inhibitor and a Selective Cyclo-Oxygenase-2 Inhibitor on Post Spinal Anesthesia Headache

• 作者: Adolphe Manzanza Kilembe David Mwembo Mutombo Emmanuel Kiyana Muyumba Franck Namegabe Zirhumana Jean Baptiste Zambeze Sakatolo Kakoma Jean Francois Brichant Olivier Kabiriko Mukuku Rivain Fefe Iteke Tinsley Mukakala Kibonge Yapo Brouh
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: Nefopam CELECOXIB HEADACHE Rachianesthesia OBSTETRICS
• 年，卷（期）: 2020,（8）
• 页码范围: 196-208
• 页数: 13页
• 分类号: R73

摘要

<span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Objective:</span></b></span></span><span><span><span><span style="font-family:""><span style="font-family:Verdana;"> To evaluate the synergistic effect of a Selective Serotonin Reuptake Inhibitor (SSRI) and a Selective Cyclooxygenase 2 Inhibitor (ISCOx-2) in the management of After Rachianesthesia Headache in Obstetric Care. </span><b><span style="font-family:Verdana;">Patients and Methods:</span></b><span style="font-family:Verdana;"> This was an experimental double-blind, randomized, multi-center clinical trial of non-inferiority clinical trials over a 12-month period (May 1, 2018 to April 30, 2019) in six hospitals in southeastern DR Congo</span></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span></span><span><span><span><span style="font-family:""><span style="font-family:Verdana;"> including all patients undergoing surgery or analgesia on spinal anesthesia for obstetrical indication and with headache characteristic of a dural breccia, with no known causes, contraindications to experimental products and informed consent to been obtained. The patients were divided into four different groups depending on the protocol used, namely: Group A = Rehydration + Paracetamol, Group B = Rehydration + Celecoxib, Group C = Rehydration + Nefopam and Group 4 = Rehydration + Celecoxib + Nefopam (Study Group). Using the Statview II software, the statistical analyzes of data obtained from the different tests were made using the ANOVA test for comparing the averages of different samples using the Fisher test. Verification of the normality of the samples was made by the Kurtosis and Skewness flattening and asymmetry test. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The protocol associating Celecoxib and Nefopam significantly demonstr