Status of serum vitamin D and neurological disorder in Nepalese population:a prospective study

• 作者: Avinash Chandra Ayush Chandra Basant Pant Pooja Prakash Pranaya Shrestha Pravesh Rajbhandari Reema Rajbhandari Resha Shrestha Samir Acharya Sharad Gajuryal
• 来源期刊: TMR生命研究
• 学科: 医学
• 关键词: Serum vitamin D Neurological disorder DEFICIENCY INCIDENCE
• 年，卷（期）: 2020,（4）
• 页码范围: 148-157
• 页数: 10页
• 分类号: R73

摘要

Background:Recently,there has been a surge in research worldwide on vitamin D.based on international level,Vit.D has shown positive correlation with cardio-cerebrovascular disorders.Regarding possible role of vitamin D there is paucity of research in low-and middle-income nations that are nearer to the equatorial area.Despite of abundant sunlight exposure,Asian people are developing hypovitaminosis D need a special consideration to avoid excessive and unnecessary usage of it.This study aims to detect the situation of vitamin D in Nepalese population and secondly to find out the suitable normalized reference range for serum vitamin D in multi-ethnic Nepalese population.Methods:A hospital based prospective study was conducted using purposive sampling technique to select 107 subjects.In-vivo and in vitro bio-physiological method was used to collect serum vitamin D level.Result:The present study showed that 32%of participants had deficit(<15 ng/mL),48%of subjects had insufficient(15 to<30 ng/mL)and 20%of participants had sufficient serum level of Vitamin-D(>30 ng/mL).Study showed that there is a lower degree of positive relationship of body mass index(r=0.162,P=0.094)and significant association of history of chronic illness(χ2=0.10,P=0.03),timing of occurrence of stroke(χ2=11.41,P=0.017)and diagnosis(χ2=21.19,P=0.011)with serum vitamin-D level at P<0.05.Conclusion:There is a direct significant association of serum vitamin D with socio-demographic variables when international unit is considered.Neurological disorder showed positive association with serum vitamin D level.