MicroRNA-155 as a potential biomarker for breast cancer screening: a systematic review and meta-analysis

• 作者: Jie-Yan Wu Qian Xiang Xiao-Qian Hao Yu-Rong Wang Yu-Sheng Liu
• 来源期刊: TMR肿瘤
• 学科: 医学
• 关键词: DIAGNOSIS MicroRNA-155 BIOMARKER Breast cancer
• 年，卷（期）: 2020,（5）
• 页码范围: 187-198
• 页数: 12页
• 分类号: R73

摘要

Background:It is aimed to evaluate the clinical significance of miR-155 on diagnosing human breast cancer.Methods:Eligible studies were identified through multiple search strategies.The search was updated up until April 10,2020.Fagan’s nomogram,publication bias,meta-regression,sensitive analysis,area under the summary receiver operating characteristic(AUC),diagnostic odds ratio as well as pooled sensitivity and specificity were utilized to assess the capacity of miR-155 for diagnosis.The meta-analysis was conducted and the origin of the heterogenic property was investigated by Stata SE 12.0 and Meta-Disc software.Results:The meta-analysis contained 9 articles totally with the AUC,diagnostic odds ratio,specificity,pooled sensitivity of 0.90(95%CI,0.88–0.93),28.63(95%CI,11.22–73.04),0.82(95%CI,0.72–0.89)and 0.86(95%CI,0.76–0.93)separately.The negative and positive likelihood ratios were 0.14 and 5.Moreover,the heterogeneity was apparent but resulted from neither sensitivity analyses nor threshold effect.Conclusion:The evidence from this study indicates that miR-155 exhibits satisfactory performance on diagnosis for breast cancer.