The Correlation between the Intrinsic and Extrinsic Molecular Markers in the Inhibition of the Lungs Carcinogenesis Growth by Mahkota Dewa Polyphenols on Balb/c Mouse

• 作者: Edi Dharmana Kustarini Samsuria Indranila Lyle E. Craker Suharyo Hadisaputro Theopilus Watuguly
• 来源期刊: 应用科学(英文)
• 学科: 医学
• 关键词: POLYPHENOLS Lungs Carcinogenesis Molecular Markers p53 Bcl-2 Bax CASPASE-8 Caspase-9 Caspase-3
• 年，卷（期）: 2020,（6）
• 页码范围: 271-286
• 页数: 16页
• 分类号: R73

摘要

<span style="font-family:Verdana;">Phytochemical analysis shows that mahkota dewa fruit contains polyphenols. Mahkota dewa polyphenols have the ability to disrupt or reverse the stages of cancer or a carcinogenesis process by affecting the intracellular signaling tissue molecules involved in an initiation and/or promotion. This chemopreventive potential is highly anticipating. The use, effectiveness, and benefits of the polyphenol have been empirically and pre-clinically proved without side effects. A multivariate analysis using Spearman’s test was conducted to examine the correlation between variables. Meanwhile, to determine which dependent variables played the strong role, a discriminant function analysis was performed with a significance level of p < 0.05 and a reliability level of 95%. The results showed that the mahkota dewa polyphenols acted as the suppressor agent by inducing apoptosis. This finding proved that polyphenols addition might result in death signal transduction through an apoptosis pathway which is either mediated by death receptor or mitochondria. The results of this study indicate that there is a relationship between apoptotic cell death mediated by death receptor and mitochondria through the administration of mahkota dewa polyphenols, it can be argued that mahkota dewa polyphenols can function in lung cancer chemoprevention in mice strain Balb/c.</span>