Formulation and Evaluation of Lipstick with Betacyanin Pigment of <i>Hylocereus polyrhizus</i>(Red Dragon Fruit)

• 作者: Cho Yi Myint Htet Htet Win Khit Chit Theeoo Lwin Wah Wah Oo
• 来源期刊: 化妆品、皮肤病及应用期刊(英文)
• 学科: 医学
• 关键词: LIPSTICK Lead BETACYANIN H. polyrhizus Quality Safety Red Dragon Fruit
• 年，卷（期）: 2020,（4）
• 页码范围: 212-224
• 页数: 13页
• 分类号: R28

摘要

Lipstick is the most widely used cosmetic product. Although lipstick gives a lot of social, psychological and therapeutic benefits, it may harm the consumers. Because most lipsticks contained high lead level and long term use of high lead level lipstick may harm the consumers. Research findings have suggested that administration of various antioxidants can prevent or subdue various toxic effects of lead and generation of oxidative stress. <strong><em>Hylocereus polyrhizus</em></strong> (Red dragon fruit) is widely available in Myanmar and it contains powerful antioxidant amaranth colorant called betacyanin pigment. It can prevent the oxidative stress caused by low level of lead, thus suitable as natural colorant for lipstick. As a role of pharmacist, this research was intended to minimize the adverse effects of lipsticks by formulating natural lipstick with betacyanin pigment obtained from <strong><em>H. polyrhizus</em></strong> and other natural ingredients. Formulation of lipstick was carried out by heating and blending method with homogenizer at a speed of 12000 rpm. Then, pH, melting point, surface abnormalities, aging stability, perfume stability and antioxidant activity were performed as quality evaluation. Skin irritation test, microbial analysis and lead content determination were carried out as safety evaluation. Formulated lipsticks with betacyanin pigment of <em><strong>H. polyrhizus</strong></em> have acceptable quality. The IC50 of standard ascorbic acid and formulated lipstick were 4.51 μg/ml and 22.23 μg/ml respectively. In quantitative analysis for microbiological control, formulated lipstick had no visible colony and in qualitative analysis, <strong><em>Staphylococcus aureus</em></strong>, <strong><em>E. coli</em></strong> and <strong><em>Pseudomonas aeruginosa</em></strong> were not detected in 0.5 g of formulated lipsticks. Moreover, lead content of formulated lipstick was only 2.9 ppm that is within allowable limit and it had negligible skin irritancy. Therefore, lipstick with betacyanin pig