Advances in Single Nucleotide Polymorphisms of Vitamin D Metabolic Pathway Genes and Respiratory Diseases

• 作者: Bingxin Xu Honghai Li Saijia Li Yingjing Du Yiyu Cai Yuxuan Wang Zhilu Li
• 来源期刊: 医学科学进展杂志(英文)
• 学科: 医学
• 关键词: Vitamin D metabolic pathway genes Single nucleotide polymorphisms Respiratory diseases
• 年，卷（期）: yxkxjzzzyw_2020,（3）
• 页码范围: 25-30
• 页数: 6页
• 分类号: R73

摘要

Vitamin D is a fat-soluble vitamin.It is an essential vitamin for human body.It has a classical effect on regulating calcium and phosphorus metabolism.Participate in cellular and humoral immune processes by regulating the growth,differentiation and metabolism of immune cells.A large number of studies in recent years have shown that vitamin D deficiency increases the incidence of respiratory diseases.Respiratory diseases mainly include bronchial asthma,chronic obstructive pulmonary disease,tuberculosis,acute upper respiratory tract infection and pneumonia.Vitamin D metabolic pathway genes play a very important regulatory role in the transformation of vitamin D into active vitamin D,including CYP2R1,CYP27B1,CYP24A1,VDBP,VDR five genes.Genetic polymorphism of genes is the molecular basis of individual differences and disease development.Therefore,this paper summarizes the research on single nucleotide polymorphism of vitamin D metabolic pathway gene and respiratory diseases.In order to provide a new idea for future treatment.