Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

• 作者: Abdurrahim Kocyigit Atilla Olgac Banu Buyukaydin Eray Metin Guler Mehmet Zorlu Muharrem Kiskac Tahsin Karaaslan
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: Diabetic neuropathy Diabetic foot Early detection Oxidative stress Thioldisulfide Visfatin protein
• 年，卷（期）: 2020,（7）
• 页码范围: 309-321
• 页数: 13页
• 分类号: R58

摘要

BACKGROUND Diabetic polyneuropathy is a very common complication of diabetes.Numerous studies are available in terms of pathogenesis.But examination methods with low reliability are still not standardized and generally time consuming.Highsensitive,easy-to-access methods are expected.Biochemical markers are one of the subjects of research.We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy.AIM To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder.METHODS A total of 392 patients with type 2 diabetes mellitus were included in the study.The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination.The biochemical parameters,oxidative stress markers,visfatin,and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs.RESULTS Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration(P<0.005).Neuropathy related symptoms were present in 20.7%of the patients,but neuropathy related findings were observed in 43.9%of the patients.Serum glucose,glycated hemoglobin,and visfatin were positively correlated with each other.Also,these parameters were positively correlated with the total oxidative stress index.Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status.Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status(P<0.005).There was no correlation between visfatin and thiol-disulphide(P=0.092,r=0.086).However,a significant negative correlation was observed between visfatin and total with native thiol(P<0.005,r=-0.338),(P<0.005,r=-0.448).CONCLUSION Diagnosis of