Evaluation of BCG Vaccine Immunogenicity in Relation to Vitamin D Status in a Group of Egyptian Children

• 作者: Amal Gaber Mohamed Azza Abdelrahman Abdelgawad Entesar Raafat Mokhtar Houda Abd El Azim Saoud Manal Ahmed Fathi
• 来源期刊: 儿科学期刊(英文)
• 学科: 医学
• 关键词: Vit D BCG Normal Weight UNDERWEIGHT
• 年，卷（期）: 2020,（2）
• 页码范围: 320-331
• 页数: 12页
• 分类号: R73

摘要

<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:""><span style="font-family:Verdana;"> Vitamin D has an immuomodulatory role in vaccine response and this may be mediated via its action on antigen presenting cells with the most potent effects on dendritic cells. </span><b><span style="font-family:Verdana;">Aim of work</span></b><span style="font-family:Verdana;">: was to determine if there is an association between circulating 25(OH)D concentrations and BCG vaccine cytokine response (interferon gamma) level. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: A cross sectional study included 80 infants aged 4 - 9 months from the pediatric outpatient clinic of Al-Zahraa university hospital (40 with normal weight and 40 with </span><span style="font-family:Verdana;">underweight). Participants were subjected to history taking, clinical examination, and laboratory investigations, particularly 25 hydroxy vitamin D [25(OH)D]</span><span style="font-family:Verdana;"> and BCG vaccine-induced interferon gamma (IFN-</span><i><span style="font-family:Verdana;">γ</span></i><span style="font-family:Verdana;">). </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: The study showed that the underweight group had a lower socioeconomic level and higher percentage of breastfeeding compared with the normal weight group. Most infants in our study received vitamin D supplementation (80% and 62.5% in normal and underweight groups, respectively). The average serum level of 25(OH)D was relatively high (>100 ng/ml) in both</span><a name="_Hlk34497752"></a><span style="font-family:Verdana;"> normal and underweight groups. The mean levels of IFN-</span><i><span style="font-family:Verdana;">γ</span></i><span style="font-family:Verdana;"> in response to BCG vaccine were not significantly different between the normal and underweight groups of infants in our study. Also, there was a statistically-significant mode