Tumor microenvironment responsive drug delivery systems

• 作者: Dongming Peng Hongjie Xiong Jianhua Yan Jun Chen Miao Mo Qunye He Shundong Cai Yanfei Liu Zhenbao Liu
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 医学
• 关键词: Cancer therapy Stimuli responsive Dynamic targeting Drug delivery system Controlled release
• 年，卷（期）: 2020,（4）
• 页码范围: 416-448
• 页数: 33页
• 分类号: R73

摘要

Conventional tumor-targeted drug delivery systems(DDSs)face challenges,such as unsatisfied systemic circulation,low targeting efficiency,poor tumoral penetration,and uncontrolled drug release.Recently,tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dilemmas.With the introduction of several additional functionalities,the properties of these smart DDSs including size,surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting,and eventually achieve desired drug release for an optimized therapeutic efficiency.This review highlights the recent research progresses on smart tumor environment responsive drug delivery systems for targeted drug delivery.Dynamic targeting strategies and functional moieties sensitive to a variety of tumor cellular stimuli,including pH,glutathione,adenosine-triphosphate,reactive oxygen species,enzyme and inflammatory factors are summarized.Special emphasis of this review is placed on their responsive mechanisms,drug loading models,drawbacks and merits.Several typical multi-stimuli responsive DDSs are listed.And the main challenges and potential future development are discussed.