Effects of Lidocaine Infusion on Quality of Recovery and Agitation after Functional Endoscopic Sinus Surgery: Randomized Controlled Study

• 作者: Rehab Abd Elraof Abd Elaziz Shahenda Shaban Shaker Abd Elaziz
• 来源期刊: 麻醉学期刊(英文)
• 学科: 数学
• 关键词: LIDOCAINE Quality of Recovery-40 Questionnaire Emergence Agitation FEES
• 年，卷（期）: 2020,（12）
• 页码范围: 435-448
• 页数: 14页
• 分类号: O17

摘要

<b><span>Background: </span></b><span>After functional endoscopic nasal surgery, emergence agitation is not uncommon. The aim of this trial was to investigate the effect of perioperative lidocaine infusion on postoperative early recovery quality and incidence of emergence agitation in patient undergoing functional endoscopic sinus surgery.</span><span> </span><b><span>Study Design:</span></b><b><span> </span></b><span>Prospective, randomized, double-blinded, placebo-controlled trial.</span><span> </span><b><span>Methods: </span></b><span>100 patients of ASA I and II, aged 18</span><span> </span><span>-</span><span> </span><span>50 years, of both sexes scheduled for FEES, were assigned into two groups. In Group L;patients received an intravenous bolus infusion of 1.5</span><span> </span><span>mg/kg lidocaine just before induction of anesthesia followed by a continuous infusion of 2</span><span> </span><span>mg/kg/h during the operation and until the end of the surgery. In Group C;patients received normal saline infusion with the same volume as group L according to the same protocol. The primary endpoints were incidence of emergence agitation and postoperative recovery quality (QoR-40) score on first postoperative day (POD1).</span><span> </span><b><span>Results:</span></b><b><span> </span></b><span>Incidence of emergence agitation was significantly lower in group L (</span><i><span>P</span></i><span> < </span><span>0</span><span>.05) compared with group C. Global QoR-40 scores on POD1 w</span><span>ere</span><span> significantly lower in both groups compared with preoperative assessment, it was significantly higher in group L on POD1 (</span><i><span>P</span></i><span> < </span><span>0</span><span>.05) than in group C. Among the five dimensions of QoR-40, the scores for physical comfort and pain were superior in group L compared to group C (</span><i><span>P</span></i><span> < </span><span>0</span><span>.05) at POD1.</span><span> </span><b><span>Conclusion: </span></b><span>Systemic lidocaine infus