Exosomal noncoding RNAs in cholangiocarcinoma:Laboratory noise or hope?

• 作者: Dimitra Ioanna Lampropoulou Dimitrios Filippou George Theodoropoulos Gerasimos Aravantinos Konstantinos Laschos Maria Gazouli Maria Piperis
• 来源期刊: 世界胃肠外科杂志:英文版(电子版)
• 学科: 医学
• 关键词: :Cholangiocarcinoma Long noncoding RNAs MICRORNAS Circular RNAs Piwi-interacting RNAs EXOSOMES Extracellular vesicles
• 年，卷（期）: 2020,（10）
• 页码范围: 407-424
• 页数: 18页
• 分类号: R73

摘要

Currently,extracellular vesicles and particularly exosomes have gained a lot of research interest due to their unique roles in several biological processes.Noncoding RNAs(microRNAs,long noncoding RNAs and circular RNAs)represent a class of functional RNA with distinct regulatory roles in tumorigenesis and cancer progression.Cholangiocarcinoma is a rare but highly aggressive type of malignancy that is very challenging to diagnose,especially in early stages;surgical resection still represents the sole potentially curative treatment option.Hence,there is an urgent need for the discovery of novel diagnostic and prognostic biomarkers.Hereby,we provide a comprehensive review of the most recent discoveries that focus on exosomal noncoding RNAs in cholangiocarcinoma with the aim to identify new molecular players that could be used as biomarkers and therapeutic targets.