Research progress on the structure and function of endomucin

• 作者: Guoxin Zhang Xingjiu Yang Ran Gao
• 来源期刊: 动物模型与实验医学（英文）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: Review Article
• 页码范围: 325-329
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/ame2.12142

摘要

Endomucin is a type I integral membrane glycoprotein, which is expressed in venous and capillary endothelial cells. It consists of 261 amino acids with an extracellular domain that is highly O -glycosylated at serine and threonine residues and has several potential N -glycosylation sites. Endomucin plays an important role in biological pro-cesses such as cell interaction, molecular cell signaling, angiogenesis and cell migra-tion, and in recent years it has also been identified as an anti-adhesion molecule and a marker of endothelial cells. While it has been shown to be involved in a number of physiological and pathological mechanisms, many of its functions remain unknown, and further study is needed. This article reviews research progress on the function of endomucin to date, in order to provide guidance for future studies.