Evolution from small molecule to nano-drug delivery systems:An emerging approach for cancer therapy of ursolic acid

• 作者: Fangmin Chen Jiali Jiang Jingwei Shao Lee Jia Mingyue Yang Ruirui Zhao Xiaotian Yuan Yifan Fang Zixuan Chen
• 来源期刊: 亚洲药物制剂科学(英文)
• 学科: 工学
• 关键词: Ursolic acid Nanosytems Carrier-free PHOTOSENSITIZER ANTICANCER
• 年，卷（期）: 2020,（6）
• 页码范围: 685-700
• 页数: 16页
• 分类号: TL9

摘要

Ursolic acid(UA),a natural pentacyclic triterpenoid,possesses widespread biological and pharmacological activities.However,drawbacks such as low bioavailability,poor targeting and rapid metabolism greatly hinder its further clinical application.Recently,with the development of nanotechnology,various UA nanosystems have emerged as promising strategies for effective cancer therapy.This article reviews various types of UA-based nanodelivery systems,primarily with emphasis placed on novel UA-based carrier-free nanodrugs,which are considered to be innovative methods for cancer therapy.Moreover,this review presents carrier-free nano-drugs that co-assembled of UA and photosensitizers that displayed synergistic antitumor performance.Finally,the article also describes the development and challenges of UA nanosystems for future research in this field.Overall,the information presented in this review will provide new insight into the rational utilization of nano-drugs in cancer therapy.